In this video summary, Dr Raj Chovatiya from Northwestern University, Chicago, Professor Martin Metz from Charité – Universitätsmedizin, Germany and Dr Andreas Pinter from Goethe University, Germany discussed the clinical signs and pathophysiology of atopic dermatitis and prurigo nodularis, the role of type 2 inflammation in the two conditions and the efficacy of Dupixent in symptom and QoL improvement, as well as the long-term drug safety profile.